DescriptionMethadone Is Included in an Opioid Category. This Was Developed by German Physicians During World War Two. Physicians Used It to Treat Patients in Severe Pain Before It Arrived in the United States. You May Also Seek It Today as Part of a Opioid or Narcotic Painkillers Rehabilitation Plan. Because It's Better Than Certain Other Medications, the Doctor Will Take Methadone Carefully. It Can Lead to Dependency or Violence. You Can Buy Methadone Online and Get Methadone for Sale Online.
Although methadone is most commonly used in the treatment of opioid use disorder, it is also used for
the treatment of chronic pain. The Prescription Review Panel of the College of Physicians and Surgeons
of British Columbia (the College), in consultation with several experienced prescribers and pharmacists,
has developed these guidelines based on best clinical evidence and experience, as a resource for
physicians who wish to prescribe methadone for the management of chronic pain.
Methadone is an oral long-acting synthetic opioid. Due to the unique pharmacokinetics of methadone,
which has a long and variable half-life and a large volume of distribution, if doses are inappropriately
high or increased too rapidly there is a risk of accumulation leading to sedation, respiratory depression
and even death. It is a drug that must be used cautiously and doses must be tailored to each patient. It is
important that physicians be familiar with methadone's unique attributes before initiating patients on
therapy. Inexperienced physicians are encouraged to consult with colleagues who are familiar with the
use of methadone, especially if considering a rapid switch method.
Physicians should carefully assess and reassess patients, particularly when initiating methadone therapy,
as the risk and onset of respiratory depression is somewhat unpredictable. Particular caution should be
exercised in elderly patients, and patients with liver disease. It is important to give consideration to the
drug interactions between methadone and other drugs that are metabolized through, or affect the
cytochrome P450 pathway. Regular review of PharmaNet facilitates this.
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